Relationship Between Calcium-Phosphorus Ratio And Parathyroid Hormone Levels In Osteoarthritic Patients
Osteoarthritic disorders (OADs) are degenerative and painful diseases, which found worldwide. The present study carried out by OPTM Research Institute aimed to determine an association between calcium-phosphorus ratio and parathyroid hormone levels in the serum of patients suffering from Osteoarthritis.
The study enrolled a total 100 patients, aged (40-≤ 80) years old (female: 73 and male: 27) having OADs in right and/or left knee joints, hip joints, ankle joints and degenerative changes in cervical and lumbar vertebrae as experimental subjects and 100 subjects with same age group (female:male = 73:27) having no OADs in any joint of the body as control subjects were considered.
5ml of peripheral blood samples were taken from each subject of both the groups and serum was used for the analysis of calcium, phosphorus, calcium-phosphorus ratio and intact-parathyroid hormone levels.
The comparative study of each level of calcium, phosphorus, calcium-phosphorus ratio with the i-PTH level in serum of experimental subjects showed lower calcium-phosphorus ratio followed by phosphorus while little higher calcium level but an increasing trend in the i-PTH level in comparison with control group. The comparison results were highly significant between calcium, phosphorus and calcium-phosphorus ratio and in the serum of experimental subjects.
The present results concluded that lowering the calcium-phosphorus ratio and higher PTH level may be a suitable
diagnostic tool to assay OADs besides radiological and MRI imaging, which is an endeavor to report in the first time. It has
already been established that excess dietary intake of calcium and phosphorus as a supplement during OADs lead to
lowering calcium-phosphorus ratio, which had adverse health impacts such as bone loss, skeleton deformities, death, etc.
Ganguly Apurba Assessment of Relationship Between Calcium-Phosphorus Ratio And Parathyroid Hormone Levels In Serum of Osteoarthritic Disordered Patients: A Diagnostic Protocol.
Journal of Dental and Medical Sciences Volume 16, Issue 12 Ver. VIII (Dec. 2017)